| Year | Title | Role | Notes |
|---|---|---|---|
| 1995 | Palookaville | Laurie | |
| 1997 | Truth or Consequences, N.M. | Addy Monroe | |
| 1998 | Zero Effect | Gloria Sullivan | |
| 1998 | Great Expectations | Maggie | |
| 1998 | Mercury Rising | Stacey | |
| 1999 | The White River Kid | Apple Lisa | |
| 2000 | Committed | Jenny | |
| 2000 | Hollow Man | Sarah Kennedy | Nominated — Blockbuster Entertainment Award for Best Supporting Actress – Science Fiction |
| 2000 | The Gift | Linda | |
| 2001 | Things Behind the Sun | Sherry | Nominated — Independent Spirit Award for Best Female Lead |
| 2003 | House of Sand and Fog | Carol Burdon | |
| 2004 | Goodnight, Joseph Parker | Muriel | |
| 2005 | Thank You for Smoking | Jill Naylor | |
| 2006 | Wild Tigers I Have Known | The Counselor | |
| 2007 | Waiting | John’s Wife | Short film |
| 2008 | Red | Carrie | |
| 2009 | One Way to Valhalla | Jenny | |
| 2009 | The Blind Side | Mrs. Boswell | |
| 2011 | Footloose | Lulu Warnicker | |
| 2012 | At Any Price | Irene Whipple | |
| 2014 | Gone Girl | Detective Rhonda Boney | Nominated — Central Ohio Film Critics Association Award for Best Ensemble Nominated — Georgia Film Critics Association Award for Best Ensemble |
| 2016 | Miss Peregrine’s Home for Peculiar Children | Maryann Portman | |
| 2018 | Lizzie | Emma Borden | |
| 2019 | The Highwaymen | Gladys Hamer | |
| 2021 | Land | Emma Mathis, Edee’s sister | Land is a 2021 drama film directed by Robin Wright in her feature directorial debut, from a screenplay by Jesse Chatham and Erin Dignam. It stars Wright, Demián Bichir and Kim Dickens. The film had its world premiere at the 2021 Sundance Film Festival on January 31, and was theatrically released in the United States on February 12, 2021, by Focus Features. It received generally positive reviews from critics. |
| 2022 | The In Between | Vickie | 11 february on Paramount + |
| 2022 | The Good Nurse | soon on netflix |